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Public release date: 24-Sep-2012
Share ] Contact: Megan Lustig
mlustig@spectrumscience.com
202-955-6222
Spectrum
BOSTON, MA (September 24, 2012) Results of the first-ever clinical drug trial for children with Progeria, a rare, fatal "rapid-aging" disease, demonstrate the efficacy of a farnesyltransferase inhibitor (FTI), a drug originally developed to treat cancer. The clinical trial results, completed only six years after scientists identified the cause of Progeria, included significant improvements in weight gain, bone structure and, most importantly, the cardiovascular system, according to The Progeria Research Foundation (PRF) and Boston Children's Hospital. The study results were published today in Proceedings of the National Academy of Sciences (Epub ahead of print).
Progeria, also known as Hutchinson-Gilford Progeria Syndrome (HGPS), is a rare, fatal genetic disease characterized by an appearance of accelerated aging in children. All children with Progeria die of the same heart disease that affects millions of normal aging adults (atherosclerosis), but instead of occurring at 60 or 70 years of age, these children may suffer heart attacks and strokes as early as age 5 years, with the average age of death at 13 years.
"To discover that some aspects of damage to the blood vessels in Progeria can not only be slowed by the FTI called lonafarnib, but even partially reversed within just 2.5 years of treatment is a tremendous breakthrough, because cardiovascular disease is the ultimate cause of death in children with Progeria," said Leslie Gordon, M.D., Ph.D., lead author of the study, medical director for PRF, and mother of a child with Progeria. In addition, Dr. Gordon is a staff scientist at Boston Children's Hospital and Harvard Medical School, and associate professor at Hasbro Children's Hospital and Alpert Medical School of Brown University.
Results Yield Improvements in One or More Study Measures for All Children
Twenty-eight children from sixteen countries participated in the two-and-a-half year drug trial, representing 75 percent of known Progeria cases worldwide at the time the trial began. Of those, 26 are children with the classic form of Progeria. The children traveled to Boston every four months to receive comprehensive medical testing through Boston Children's Hospital's Clinical and Translational Study Unit.
Treatment consisted of the FTI lonafarnib, supplied by Merck & Co., given to children orally, twice-a-day over the course of the study, under the supervision of principal investigator Mark Kieran, M.D., Ph.D., director of pediatric medical neuro-oncology at the Dana-Farber/Children's Hospital Cancer Center.
The research team, which included specialists at Boston Children's Hospital, Brigham & Women's Hospital and Dana-Farber Cancer Institute, evaluated the children's rate of weight gain compared to their pre-therapy rate as the primary outcome because children with Progeria experience severe failure to thrive, and have a consistent, very slow linear rate of weight gain over time. Researchers also examined arterial stiffness (a predictor of heart attack and stroke in the general population), bone density and rigidity (indicators of osteoporosis). Every child completing the study showed improvement in an ability to gain additional weight, increased flexibility of blood vessels or improved bone structure.
Results included improvement in one or more of the following areas:
Following the 2003 discovery of the gene that causes Progeria, researchers identified FTIs as a potential drug treatment for Progeria. Children with Progeria have a genetic mutation that leads to the production of the protein progerin, which is responsible for Progeria. Progerin blocks normal cell function and part of its toxic effect on the body is caused by a molecule called a "farnesyl group," which attaches to the progerin protein. FTIs act by blocking the attachment of the farnesyl group onto progerin.
"In the early stages of planning for this clinical trial, we realized that my team's experience using FTIs to treat children with brain cancer could bring together PRF's preclinical research efforts and the expertise we needed to study the drug in children with Progeria," said Kieran, the study's senior author and associate professor of Pediatrics at Harvard Medical School. "The premise behind studying this drug was that by stopping the attachment of the farnesyl group onto progerin in children with Progeria, progerin may be inactivated, reducing some effects of the disease."
"PRF provides a model for disease research organizations, and is a good example of successful translational research, moving from gene discovery to clinical treatment at an unprecedented pace," added Dr. Kieran.
Since PRF's founding in 1999, the organization and its scientific partners have identified the genetic mutation that causes the disease, funded preclinical research and funded clinical trials. A second clinical trial, funded by the National Institutes of Health and PRF, is currently underway and more trials are expected to follow.
"The partnership between The Progeria Research Foundation, the research team and these courageous families was essential for success," said Dr. Gordon. "It required identifying children and their home doctors from around the globe, obtaining the essential pre-trial clinical information, transporting families to and from Boston, supplying translators both inside and outside of the hospital setting, and putting together a multidisciplinary clinical team to assess treatment effects. But it was all worth it, and I believe we have set in motion a blueprint for successful treatment trials for children with Progeria and for other rare diseases."
"The results of this study provide our family with excitement and hope for Megan's future," said Sandy Nighbor, mother of Megan, a 12-year-old child who participated in the clinical trial. "We're grateful to The Progeria Research Foundation and all of the doctors for their commitment to helping my daughter and all children with Progeria."
Progeria Linked to Normal Aging Process
Previous research shows that progerin is also produced in the general population and increases in the body with age. A number of studies successfully linked progerin with normal aging, including a causal link between progerin and genetic instability, specifically telomere dysfunction in the aging process. Researchers plan to continue researching the effect of FTIs, which may help scientists learn more about cardiovascular disease that affects millions, as well as the normal aging process.
"One of the main reasons we achieved breakthrough results in this first trial is because of the tremendous supporters who provided funding, and helped get us one step closer to achieving our ultimate goal a cure for Progeria," said Audrey Gordon, Executive Director of PRF. "Every donation makes a difference. With continued support, we will fund research that will not only allow children with Progeria around the world to live long and healthy lives, but may also advance our understanding of the normal aging process that affects us all."
###
About The Progeria Research Foundation (PRF)
The Progeria Research Foundation (PRF) was established in 1999 to find the cause, treatment and cure for Progeria a rapid aging disease that causes children to die from heart disease or stroke at an average age of 13 years. In the past 13 years, research conducted in partnership with PRF has identified the gene that causes Progeria and possible treatments. PRF funded and coordinated this first-ever Progeria clinical trial. PRF is currently funding a clinical trial in which children with Progeria receive FTI plus two additional medications to slow the progression of Progeria. PRF continues to identify more children who can benefit from the programs and services that it provides while helping advance research towards treatment and cure. To learn more about Progeria and what you can do to help, please visit www.progeriaresearch.org.
About Boston Children's Hospital
Boston Children's Hospital is home to the world's largest research enterprise based at a pediatric medical center, where its discoveries have benefited both children and adults since 1869. More than 1,100 scientists, including nine members of the National Academy of Sciences, 11 members of the Institute of Medicine and nine members of the Howard Hughes Medical Institute comprise Boston Children's research community. Founded as a 20-bed hospital for children, Boston Children's today is a 395 bed comprehensive center for pediatric and adolescent health care grounded in the values of excellence in patient care and sensitivity to the complex needs and diversity of children and families. Boston Children's also is the primary pediatric teaching affiliate of Harvard Medical School. For more information about research and clinical innovation at Boston Children's, visit: http://vectorblog.org/.
About the Dana-Farber/Children's Hospital Cancer Center
Dana-Farber/Children's Hospital Cancer Center (DF/CHCC) combines the strengths of Dana-Farber Cancer Institute, a world-class cancer institute, and Boston Children's Hospital, an internationally known pediatric hospital. For over 60 years, these two Harvard Medical School affiliates have provided comprehensive care for children and adolescents with cancer. Committed to conducting research to better understand and treat childhood cancers, DF/CHCC is the Pediatric Oncology Experimental Therapeutics Investigator Consortium's (POETIC) only Phase I Clinical Trial site in New England, and is home to one of the world's most sophisticated and accomplished Pediatric Stem Cell Transplantation centers. DF/CHCC also offers comprehensive transitional and long-term survivorship programs to childhood cancer survivors of all ages.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 24-Sep-2012 Share ] Contact: Megan Lustig
mlustig@spectrumscience.com
202-955-6222
Spectrum
BOSTON, MA (September 24, 2012) Results of the first-ever clinical drug trial for children with Progeria, a rare, fatal "rapid-aging" disease, demonstrate the efficacy of a farnesyltransferase inhibitor (FTI), a drug originally developed to treat cancer. The clinical trial results, completed only six years after scientists identified the cause of Progeria, included significant improvements in weight gain, bone structure and, most importantly, the cardiovascular system, according to The Progeria Research Foundation (PRF) and Boston Children's Hospital. The study results were published today in Proceedings of the National Academy of Sciences (Epub ahead of print).
Progeria, also known as Hutchinson-Gilford Progeria Syndrome (HGPS), is a rare, fatal genetic disease characterized by an appearance of accelerated aging in children. All children with Progeria die of the same heart disease that affects millions of normal aging adults (atherosclerosis), but instead of occurring at 60 or 70 years of age, these children may suffer heart attacks and strokes as early as age 5 years, with the average age of death at 13 years.
"To discover that some aspects of damage to the blood vessels in Progeria can not only be slowed by the FTI called lonafarnib, but even partially reversed within just 2.5 years of treatment is a tremendous breakthrough, because cardiovascular disease is the ultimate cause of death in children with Progeria," said Leslie Gordon, M.D., Ph.D., lead author of the study, medical director for PRF, and mother of a child with Progeria. In addition, Dr. Gordon is a staff scientist at Boston Children's Hospital and Harvard Medical School, and associate professor at Hasbro Children's Hospital and Alpert Medical School of Brown University.
Results Yield Improvements in One or More Study Measures for All Children
Twenty-eight children from sixteen countries participated in the two-and-a-half year drug trial, representing 75 percent of known Progeria cases worldwide at the time the trial began. Of those, 26 are children with the classic form of Progeria. The children traveled to Boston every four months to receive comprehensive medical testing through Boston Children's Hospital's Clinical and Translational Study Unit.
Treatment consisted of the FTI lonafarnib, supplied by Merck & Co., given to children orally, twice-a-day over the course of the study, under the supervision of principal investigator Mark Kieran, M.D., Ph.D., director of pediatric medical neuro-oncology at the Dana-Farber/Children's Hospital Cancer Center.
The research team, which included specialists at Boston Children's Hospital, Brigham & Women's Hospital and Dana-Farber Cancer Institute, evaluated the children's rate of weight gain compared to their pre-therapy rate as the primary outcome because children with Progeria experience severe failure to thrive, and have a consistent, very slow linear rate of weight gain over time. Researchers also examined arterial stiffness (a predictor of heart attack and stroke in the general population), bone density and rigidity (indicators of osteoporosis). Every child completing the study showed improvement in an ability to gain additional weight, increased flexibility of blood vessels or improved bone structure.
Results included improvement in one or more of the following areas:
Following the 2003 discovery of the gene that causes Progeria, researchers identified FTIs as a potential drug treatment for Progeria. Children with Progeria have a genetic mutation that leads to the production of the protein progerin, which is responsible for Progeria. Progerin blocks normal cell function and part of its toxic effect on the body is caused by a molecule called a "farnesyl group," which attaches to the progerin protein. FTIs act by blocking the attachment of the farnesyl group onto progerin.
"In the early stages of planning for this clinical trial, we realized that my team's experience using FTIs to treat children with brain cancer could bring together PRF's preclinical research efforts and the expertise we needed to study the drug in children with Progeria," said Kieran, the study's senior author and associate professor of Pediatrics at Harvard Medical School. "The premise behind studying this drug was that by stopping the attachment of the farnesyl group onto progerin in children with Progeria, progerin may be inactivated, reducing some effects of the disease."
"PRF provides a model for disease research organizations, and is a good example of successful translational research, moving from gene discovery to clinical treatment at an unprecedented pace," added Dr. Kieran.
Since PRF's founding in 1999, the organization and its scientific partners have identified the genetic mutation that causes the disease, funded preclinical research and funded clinical trials. A second clinical trial, funded by the National Institutes of Health and PRF, is currently underway and more trials are expected to follow.
"The partnership between The Progeria Research Foundation, the research team and these courageous families was essential for success," said Dr. Gordon. "It required identifying children and their home doctors from around the globe, obtaining the essential pre-trial clinical information, transporting families to and from Boston, supplying translators both inside and outside of the hospital setting, and putting together a multidisciplinary clinical team to assess treatment effects. But it was all worth it, and I believe we have set in motion a blueprint for successful treatment trials for children with Progeria and for other rare diseases."
"The results of this study provide our family with excitement and hope for Megan's future," said Sandy Nighbor, mother of Megan, a 12-year-old child who participated in the clinical trial. "We're grateful to The Progeria Research Foundation and all of the doctors for their commitment to helping my daughter and all children with Progeria."
Progeria Linked to Normal Aging Process
Previous research shows that progerin is also produced in the general population and increases in the body with age. A number of studies successfully linked progerin with normal aging, including a causal link between progerin and genetic instability, specifically telomere dysfunction in the aging process. Researchers plan to continue researching the effect of FTIs, which may help scientists learn more about cardiovascular disease that affects millions, as well as the normal aging process.
"One of the main reasons we achieved breakthrough results in this first trial is because of the tremendous supporters who provided funding, and helped get us one step closer to achieving our ultimate goal a cure for Progeria," said Audrey Gordon, Executive Director of PRF. "Every donation makes a difference. With continued support, we will fund research that will not only allow children with Progeria around the world to live long and healthy lives, but may also advance our understanding of the normal aging process that affects us all."
###
About The Progeria Research Foundation (PRF)
The Progeria Research Foundation (PRF) was established in 1999 to find the cause, treatment and cure for Progeria a rapid aging disease that causes children to die from heart disease or stroke at an average age of 13 years. In the past 13 years, research conducted in partnership with PRF has identified the gene that causes Progeria and possible treatments. PRF funded and coordinated this first-ever Progeria clinical trial. PRF is currently funding a clinical trial in which children with Progeria receive FTI plus two additional medications to slow the progression of Progeria. PRF continues to identify more children who can benefit from the programs and services that it provides while helping advance research towards treatment and cure. To learn more about Progeria and what you can do to help, please visit www.progeriaresearch.org.
About Boston Children's Hospital
Boston Children's Hospital is home to the world's largest research enterprise based at a pediatric medical center, where its discoveries have benefited both children and adults since 1869. More than 1,100 scientists, including nine members of the National Academy of Sciences, 11 members of the Institute of Medicine and nine members of the Howard Hughes Medical Institute comprise Boston Children's research community. Founded as a 20-bed hospital for children, Boston Children's today is a 395 bed comprehensive center for pediatric and adolescent health care grounded in the values of excellence in patient care and sensitivity to the complex needs and diversity of children and families. Boston Children's also is the primary pediatric teaching affiliate of Harvard Medical School. For more information about research and clinical innovation at Boston Children's, visit: http://vectorblog.org/.
About the Dana-Farber/Children's Hospital Cancer Center
Dana-Farber/Children's Hospital Cancer Center (DF/CHCC) combines the strengths of Dana-Farber Cancer Institute, a world-class cancer institute, and Boston Children's Hospital, an internationally known pediatric hospital. For over 60 years, these two Harvard Medical School affiliates have provided comprehensive care for children and adolescents with cancer. Committed to conducting research to better understand and treat childhood cancers, DF/CHCC is the Pediatric Oncology Experimental Therapeutics Investigator Consortium's (POETIC) only Phase I Clinical Trial site in New England, and is home to one of the world's most sophisticated and accomplished Pediatric Stem Cell Transplantation centers. DF/CHCC also offers comprehensive transitional and long-term survivorship programs to childhood cancer survivors of all ages.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-09/s-ftf092412.php
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By Herb Weisbaum, NBC News contributor
A just-released study by Bankrate.com finds that checking account fees have hit unprecedented highs. At the same time, it?s becoming harder to get a truly free checking account, one with no strings attached.
Here are the key findings from the Bankrate 2012 Checking Survey:
As fees go up, ?free? checking ? with no minimum balance requirement and no monthly fee ? continues its march toward extinction.?
?And that?s going to continue over the next few years,? said Bankrate?s senior financial analyst Greg McBride. ?I don?t expect it to reverse anytime soon.??
The Bankrate survey shows that only 39 percent of the major banks in the U.S. offer non-interest checking accounts that have no fee. That?s down from a peak of 76 percent just three years ago and 45 percent in 2011.?
Why is this happening??
Bankers are responding to new federal regulations that have reduced their revenue from both overdraft fees and debit card swipe fees.?
?Free checking accounts have become the casualty of those regulatory changes,? McBride said. ?Rather than handing out that free checking to everybody who walks through the door, you typically have to have some other relationship or business with the bank.?
You can avoid the fees
Bankrate found that with most non-interest checking accounts ? about 95 percent ? there are ways to avoid the fees.
?The easiest way to get your account for free is to sign up for direct deposit,? McBride said. ?That?s the most common string attached and it?s a pretty low hurdle to clear.?
Some banks require a minimum balance to waive the fee and that amount continues to rise. In some cases, it can be thousands of dollars. According to the Bankrate survey, the average minimum balance to avoid a fee now stands at $723, an increase of 23 percent from last year.
There is another option: move your money. Look for a financial institution ? a credit union, community bank or online bank ? that offers totally free checking with no requirements to qualify. Bankrate found that 72 percent of the largest credit unions still offer free checking.
Consumers Union, the advocacy arm of Consumer Reports, has prepared a tip sheet on how to move your money to a new checking account.?
Skip most interest-bearing checking accounts
Bankrate found that these accounts have become even less attractive in the last year.
They have higher fees than non-interest accounts and require a larger balance to have those fees waived.?
More importantly, the yields are ridiculously low. The average interest-bearing checking account in the U.S. right now pays a paltry 0.05 percent. If you had $250,000 in that account for a year, you?d only earn $125.?
?This is not an efficient use of cash,? McBride said. The interest earnings you receive are a pittance and really don?t justify tying up that amount of money at very low and uncompetitive rates of return.??
Beat the banks
Most bank penalty fees can be avoided and it?s not all that difficult to do. You just need to remember what triggers a fee and act accordingly.?
Plan ahead if you need cash?
Only use your bank?s ATM or one that is in-network. In a pinch, make a purchase with your credit or debit card and get some cash back. That way, there?s no fee.?
Avoid overdraft fees?
We all make mistakes, but you?ll get clobbered if you overdraw your account. Monitor your account: keep track of automatic bill payments, debit card charges and cash withdrawals. It?s easy to check your balance online or on the phone. See if you bank offers email or text alerts that let you know when your checking account balance drops below a level you set.?
Link your checking account to a savings account that can be tapped if you overdraw. That service is a lot cheaper than paying an overdraft fee.?
If you want to prevent overdraws with a debit card (and avoid NSF fees) don?t opt-in to the bank?s overdraft protection program. Sign up for this ?courtesy? service and you will be able to overdraw your checking account when you make a purchase with your debit card ? and you?ll pay a hefty fee if you do. Without debit card overdraft protection the transaction will be declined at the register if you?re about to trigger an overdraft.?
Do you know if you have overdraft protection on your debit card account? If you?re not sure, call your bank.
ConsumerMan: Customers still confused about overdraft protection?
Herb Weisbaum is The ConsumerMan. Follow him on Facebook or visit The ConsumerMan website.
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Chasing 79, Sri Lanka managed 46 for five in seven overs.
Rain played spoilsport but failed to dampened the spirit of the 34,000 spectators, who had turned up for the first Twenty20 international between Sri Lanka and South Africa.
The start of the match was delayed by two-and-a-half-hours and when rain stopped only seven overs per side were possible.
Sri Lanka won the toss and skipper Mahela Jayawardene decided to bowl first. Nuwan Kulasekara struck in the very first over to get rid of the dangerous Richard Levi with Dilshan Munaweera taking one of the best catches in the tournament so far.
But it was the captain's knock of 15-ball 30 by AB de Villiers that took away the match from Sri Lankans. Hashim Amla (16), Faf du Plessis (13) and Jean Paul Duminy (13 nout out) also came up with valuable runs.
In reply, Sri Lanka kept losing wickets at regular intervals. Munaweera and Kumar Sangakkara were the only two batsmen, who got to double figures scoring identical 13.
Both teams have moved into the Super Eight Stage.
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NEW YORK/MIAMI (Reuters) - Marc Leder, the host of the fundraiser where Mitt Romney labeled 47 percent of Americans as people who paid no tax and believed the government has a responsibility to care for them, has spent most of his career in relative obscurity.
But the 50-year-old private equity executive, who made his fortune buying and selling distressed companies, has been thrust into the headlines, finding his way first into the tabloids as the result of a contentious divorce and raucous parties and, more recently, onto the front pages thanks to the Romney event.
Leder, co-founder of Sun Capital Partners Inc, held the $50,000-a-plate fundraiser in May at his Boca Raton, Florida, home during which the Republican presidential candidate was secretly video taped dismissing Obama's supporters - almost half the country's voters - as too dependent on government.
The tape was released this week and put Romney on the defensive in the face of accusations from Democrats that he didn't care about the poor or the middle class and wouldn't be a president for all Americans.
"I hosted a fundraiser for an old friend in May," Leder said in a statement provided by his firm's spokesman, who declined to comment further for this article.
"I believe all Americans should have the opportunity to succeed, to improve their lives, and to build even better lives for their children. I have supported people from both political parties who share this view and make it a priority, even though their ideas on how to achieve it may differ."
The financier has thrown his financial weight behind Romney, an "old friend" Leder credits with inspiring his move from investment banking into private equity. Out of the $337,000 Leder has spent in political donations in this election season, $321,600 has gone to Mitt Romney and other Republicans and Republican-aligned groups, according to Reuters calculations.
People who know Leder describe him as the quintessential private equity executive - a confident, outgoing personality, who is interested in even the smallest details at the more than 80 companies owned by his firm.
"He is very much into detail ... He focuses on the garnish on a plate and says why do you need to put a pickle on a plate if nobody's eating it?" said George Michel, CEO of Sun Capital portfolio company Boston Market, a fast food chain.
Michel described Leder as being a relentless optimist who works all hours, but finds time for his children.
Leder has also followed in the footsteps of other prominent private equity executives such as Blackstone Group LP's Stephen Schwarzman by drawing attention for his lavish parties and lifestyle.
Controversy has plagued Leder of late. His private equity firm is one of those being investigated by the New York state attorney general for potential tax dodging, a source familiar with the matter told Reuters earlier this month.
TABLOID TARGET
A father of two daughters and one son, Leder divorced his wife of 22 years in 2009 after she cheated on him with their children's 23-year-old tennis coach, according to court papers filed by Leder's lawyer in their divorce proceedings.
His ex-wife, Lisa, did not immediately return a phone call seeking comment. A lawyer for her did not respond to a request for comment.
Leder's ex-wife described him in a 2009 divorce filing as a very successful private equity investor with "enormous annual income."
The Leders "enjoy a very high standard of living including multiple multi-million dollar homes, private jet travel and other luxuries," said the divorce petition, which was filed by his ex-wife's lawyer and included a request the court determine how their assets should be distributed.
Lawyers for both argued over the value of the couple's estate at the time. An attorney for Lisa Leder put the couple's marital estate at $400 million, while a lawyer representing Marc Leder said the value stood at more than $100 million.
The issue was at the center of a months-long legal battle as Leder's ex-wife sought documents and other testimony to determine the value of Sun Capital and Leder's stake in the firm.
Court documents filed by both of their lawyers and a transcript of a June 2009 court hearing depicted a lavish lifestyle that included a 10,000-square-foot mansion in Boca Raton, Florida, a family vacation house in the ski resort town of Stowe, Vermont, personal staff and a Sun Capital employee responsible for paying the family's bills.
Leder's parties in the Hamptons and St. Barts drew the attention of the New York Post. The paper described one Bridgehampton party as being "as if the Playboy Mansion met the East End," citing attendees describing nudity and public sex acts.
Leder has never commented on such claims, but has denied hosting wild and crazy parties.
Sources who know Leder paint a mixed picture of him following his divorce. Some said he devoted less time to the firm to pursue recreational activities and dating. Others said his reputation as someone who likes to party a lot is unwarranted.
"He's not as colorful as they make him out to be. I could certainly point to a lot of private equity executives who would be a lot more flamboyant. And he is only working harder. He has not slackened off at all, maybe just the opposite," said Cliff Roesler, managing director at Angle Advisors, who's known Leder for seven years and socialized with him.
FOLLOWING IN ROMNEY'S FOOTSTEPS
Like Romney, Leder made his fortune in the private equity industry, using money from investors to buy companies and sell them at a profit. He co-founded Sun Capital in 1995 with fellow Lehman veteran Roger Krause and his firm has since invested in more than 300 companies and amassed about $8 billion of capital under management.
Romney played a key role in Leder's career. As an investment banker, Leder would talk to Romney about deals. When Leder launched Sun Capital, Romney was an early backer, investing in the new firm's deals. Sources familiar with the two men say that they have been close ever since.
Romney's old firm, Bain Capital LLC, and Sun have also remained close, with Sun buying some non-core businesses of companies that Bain acquired.
But while Bain carried out leveraged buyouts, Sun focused on a subset of such deals involving companies in various degrees of distress in need of a major turnaround. About a third of the companies that Sun invests in have negative cash flows.
This can make deals very lucrative should they work out. Earlier this year, Sun Capital sold transmission parts manufacturer Raybestos Powertrain LLC, making 110 times its money, according to a person familiar with the matter.
But such transactions come with much more risk. Sun Capital has seen several companies file for bankruptcy on its watch, including ice cream maker Friendly's, cargo and utility trailer manufacturer Pace American and auto parts supplier Mark IV Industries.
"He is great and talented person and has done a great job in building Sun," said Gilbert Harrison, chairman of Financo LLC, a New York-based investment banking firm where Leder started his career.
Sun Capital is currently fundraising, seeking $3 billion from investors for its sixth buyout fund, according to sources.
Its fifth fund was valued at 1.23 times its investment cost as of the end of July according to the Oklahoma Police Pension and Retirement System, not a stellar performance but better than many other private equity firms that launched in 2007, at the height of the credit bubble preceding the financial crisis.
Their fifth fund is not among the top performing 25 percent of private equity funds launched in 2007, according to data firm Preqin, but is in the second quartile.
Leder's political contributions go beyond Republican candidates. Excluding his support for Romney, from 2002 to present he's given $63,200 to Republicans and $44,900 to Democrats.
He is also friendly with hip hop entrepreneur and liberal activist Russell Simmons and has supported his non-profit work in the arts.
"Marc Leder is a friend of mine and has been for many years," Simmons said in a statement. "While Marc and I have different views on American politics, we share the same view on giving back."
Aside from Simmons' Art for Life charity, Leder also donates to charities, including Best Buddies International, which fosters friendships between people with and without intellectual disabilities, and the Samuel Waxman Cancer Research Foundation.
(Additional reporting by Alexander Cohen in Washington, D.C. and David Toll in New York; Writing by Michael Erman; Editing by Paritosh Bansal, Martin Howell and Andre Grenon; Desking by Vicki Allen)
(This story was corrected to change Leder's age in paragraph 2 after his spokesman changed the age provided from 51 to 50)
Source: http://news.yahoo.com/spotlight-romney-fundraising-host-leder-193610357--sector.html
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Getty ImagesEli Manning celebrates after a touchdown during the Giants' 23-0 victory over the Panthers on Thursday.
By AARON BEARD
updated 11:59 p.m. ET Sept. 20, 2012
CHARLOTTE, N.C. - Eli Manning didn't need a scintillating fourth quarter comeback Thursday night.
The two-time Super Bowl champion quarterback, running back Andre Brown and the rest of the New York Giants were too good for the first three quarters to need one.
Brown ran for a career-high 113 yards and two touchdowns in his first NFL start and the routed the Carolina Panthers 36-7.
Four days after rallying from 14 points down to beat Tampa Bay, the Giants dominated the first half, scoring on their first four possessions to build a 20-0 lead.
The defending champion Giants (2-1) were without three starters but it hardly mattered.
Brown got the start in place of Ahmad Bradshaw, who sat out with a neck injury. Ramses Barden caught nine passes for a career-high 138 yards in his first NFL start in place of Hakeem Nicks.
Manning completed 27 of 35 passes for 288 yards with one touchdown and no interceptions.
Cam Newton struggled all night and was pressured into three interceptions. The Panthers (1-2) had five turnovers, including two by returner Joe Adams.
Mixing run and pass, the Giants dominated the opening half, outgaining the Panthers 303-125.
Manning completed 19 of 25 passes for 208 yards in the first half, including a 14-yard touchdown pass to Martellus Bennett to cap the Giants' game-opening drive and set the tone. It capped an eight-play, 80-yard drive and marked the third straight game the Panthers have given up a touchdown on an opponent's first drive.
Brown repeatedly bounced off tacklers and Barden had little trouble getting open against a Carolina defense that failed to pressure Manning.
Brown ran 13 times for 71 yards and a touchdown last week against Tampa Bay and surpassed that total by the end of the first quarter with 77 yards on seven.
Barden had 123 yards on seven carries at halftime.
Before Thursday night, the fourth-year receiver had never managed more than nine catches for 94 yards receiving in a season.
Any hopes that the Panthers would turn things around in the second half were slowed when rookie returner Joe Adams of the ball on the opening kickoff resulting in another field goal for Lawrence Tynes.
The Panthers didn't get on the board until midway through the third quarter when Newton leaped over the pile from a yard out.
NOTES: For the third straight week Carolina receiver Steve Smith sparred with an opposing cornerback during the game. This week's victim was Corey Webster. ... Panthers running back Jonathan Stewart missed his second game of the season because of a toe injury. The Panthers also were without tackle Byron Bell. ... The Panthers honored Olympic gold medal swimmers Cullen Jones and Ricky Berens.
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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More newsGetty Images??Eli Manning didn't need a big comeback Thursday night, not with Andre Brown running for a career-high 113 yards and two touchdowns in the New York Giants' 36-7 victory over the Carolina Panthers.
Source: http://nbcsports.msnbc.com/id/49113123/ns/sports-nfl/
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AMMAN (Reuters) - Rebel fighters trying to oust President Bashar al-Assad shot down a fighter jet as it flew over the northern Syrian town of Atarib in Idlib province, a witness said.
The witness, an independent journalist who asked to remain anonymous, said rebel fighters were attacking a military base near the town when the jet flew over and rebels shot it down with anti-aircraft guns.
Vastly outgunned, rebels say they need surface-to-air missiles to take down planes and helicopters used by the Syrian military to bombard opposition strongholds.
Fighters use outdated anti-aircraft machine guns that are welded to pickup trucks but they are inaccurate and useless if the military aircraft fly above a certain altitude.
On August 27 fighters shot down a helicopter on the outskirts of Damascus and three days later rebels said they had brought down a jet in Idlib, near the Turkish border.
Activists say more than 27,000 people, mostly civilians, have been killed in the 18-month-old revolt in Syria, which began with peaceful street protests that provoked a military crackdown and mushroomed into civil war.
Despite calling for Assad to step down, the West is wary of arming disparate rebel groups.
(Writing by Oliver Holmes; Editing by Rosalind Russell)
Source: http://news.yahoo.com/rebels-down-fighter-jet-northern-syria-witness-090328063.html
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Public release date: 13-Sep-2012 Share ] Contact: Tamara Moore
tmoore@gymr.com
202-745-5114
Society for Healthcare Epidemiology of America
CHICAGO (September 13, 2012) New research demonstrates that daily cleaning of high-touch surfaces in isolation rooms of patients with Clostridium difficile (C. difficile) or methicillin-resistant Staphylococcus aureus (MRSA) significantly reduces the rate of the pathogens on the hands of healthcare personnel. The findings underscore the importance of environmental cleaning for reducing the spread of difficult to treat infections. The study is published in the October issue of Infection Control and Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America (SHEA).
Researchers from the Cleveland Veterans Affairs Medical Center conducted a prospective, randomized trial comparing regular cleaning protocols of housekeeping staff with daily disinfection of high-touch surfaces performed by researchers (i.e., bed rail and bedside tables, call button and phone, and toilet seat, and bathroom hand rail) in 34 C. difficile and 36 MRSA isolation rooms. The study assessed hand contamination of physicians, nurses, and research staff six to eight hours after disinfection procedures. In rooms with daily disinfection, there were significant reductions in the amount and frequency of pathogens on the hands of investigators and healthcare personnel caring for the patients (6.4% with daily disinfection versus 30% with standard cleaning).
"These findings add to the growing body of evidence supporting environmental cleaning and disinfection as an important infection control strategy," said Sirisha Kundrapu, MD, a lead author of the study. "The intervention was simple, inexpensive, and well-accepted by patients and staff."
Regular cleaning protocols of housekeeping staff include disinfection of patient rooms with sodium hypochlorite after discharge, daily cleaning of bathrooms and floors, and cleaning of high-touch surfaces only if visibly soiled. During the study period, less than 10 percent of high-touch surfaces in C. difficile or MRSA rooms were cleaned daily using regular protocols. Rooms randomized to daily disinfection were cleaned each morning for seven days, or until discharge. The daily disinfection took about 20 minutes per room.
The study highlights the impact small changes in environmental cleaning can have on preventing transmission and patient exposure to harmful pathogens, but has several limitations. Limitations of the study include daily disinfection performed by research staff rather than by housekeeping staff of the medical center, researchers did not measure adherence to hand hygiene and contact precautions for the healthcare workers whose hands were cultured and did not attempt to assess whether healthcare worker hand contamination was due to noncompliance with glove use or lack of proper technique when removing gloves. Molecular typing was not performed to determine whether hand isolates matched environmental isolates.
###
Published through a partnership between the Society for Healthcare Epidemiology of America and The University of Chicago Press, Infection Control and Hospital Epidemiology provides original, peer-reviewed scientific articles for anyone involved with an infection control or epidemiology program in a hospital or healthcare facility. ICHE is ranked 15 out of 140 journals in its discipline in the latest Journal Citation Reports from Thomson Reuters.
SHEA is a professional society representing more than 2,000 physicians and other healthcare professionals around the world with expertise in healthcare epidemiology and infection prevention and control. SHEA's mission is to prevent and control healthcare-associated infections and advance the field of healthcare epidemiology. The society leads this field by promoting science and research and providing high-quality education and training in epidemiologic methods and prevention strategies. SHEA upholds the value and critical contributions of healthcare epidemiology to improving patient care and healthcare worker safety in all healthcare settings. Visit SHEA online at www.shea-online.org, facebook.com/SHEApreventingHAIs and @SHEA_Epi.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 13-Sep-2012 Share ] Contact: Tamara Moore
tmoore@gymr.com
202-745-5114
Society for Healthcare Epidemiology of America
CHICAGO (September 13, 2012) New research demonstrates that daily cleaning of high-touch surfaces in isolation rooms of patients with Clostridium difficile (C. difficile) or methicillin-resistant Staphylococcus aureus (MRSA) significantly reduces the rate of the pathogens on the hands of healthcare personnel. The findings underscore the importance of environmental cleaning for reducing the spread of difficult to treat infections. The study is published in the October issue of Infection Control and Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America (SHEA).
Researchers from the Cleveland Veterans Affairs Medical Center conducted a prospective, randomized trial comparing regular cleaning protocols of housekeeping staff with daily disinfection of high-touch surfaces performed by researchers (i.e., bed rail and bedside tables, call button and phone, and toilet seat, and bathroom hand rail) in 34 C. difficile and 36 MRSA isolation rooms. The study assessed hand contamination of physicians, nurses, and research staff six to eight hours after disinfection procedures. In rooms with daily disinfection, there were significant reductions in the amount and frequency of pathogens on the hands of investigators and healthcare personnel caring for the patients (6.4% with daily disinfection versus 30% with standard cleaning).
"These findings add to the growing body of evidence supporting environmental cleaning and disinfection as an important infection control strategy," said Sirisha Kundrapu, MD, a lead author of the study. "The intervention was simple, inexpensive, and well-accepted by patients and staff."
Regular cleaning protocols of housekeeping staff include disinfection of patient rooms with sodium hypochlorite after discharge, daily cleaning of bathrooms and floors, and cleaning of high-touch surfaces only if visibly soiled. During the study period, less than 10 percent of high-touch surfaces in C. difficile or MRSA rooms were cleaned daily using regular protocols. Rooms randomized to daily disinfection were cleaned each morning for seven days, or until discharge. The daily disinfection took about 20 minutes per room.
The study highlights the impact small changes in environmental cleaning can have on preventing transmission and patient exposure to harmful pathogens, but has several limitations. Limitations of the study include daily disinfection performed by research staff rather than by housekeeping staff of the medical center, researchers did not measure adherence to hand hygiene and contact precautions for the healthcare workers whose hands were cultured and did not attempt to assess whether healthcare worker hand contamination was due to noncompliance with glove use or lack of proper technique when removing gloves. Molecular typing was not performed to determine whether hand isolates matched environmental isolates.
###
Published through a partnership between the Society for Healthcare Epidemiology of America and The University of Chicago Press, Infection Control and Hospital Epidemiology provides original, peer-reviewed scientific articles for anyone involved with an infection control or epidemiology program in a hospital or healthcare facility. ICHE is ranked 15 out of 140 journals in its discipline in the latest Journal Citation Reports from Thomson Reuters.
SHEA is a professional society representing more than 2,000 physicians and other healthcare professionals around the world with expertise in healthcare epidemiology and infection prevention and control. SHEA's mission is to prevent and control healthcare-associated infections and advance the field of healthcare epidemiology. The society leads this field by promoting science and research and providing high-quality education and training in epidemiologic methods and prevention strategies. SHEA upholds the value and critical contributions of healthcare epidemiology to improving patient care and healthcare worker safety in all healthcare settings. Visit SHEA online at www.shea-online.org, facebook.com/SHEApreventingHAIs and @SHEA_Epi.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-09/sfhe-ddo091312.php
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Public release date: 13-Sep-2012 Share ] Contact: Sarah Hoyle
s.hoyle@exeter.ac.uk
44-013-927-22062
University of Exeter
Scientists have found the answer to why female killer whales have the longest menopause of any non-human species - to care for their adult sons. Led by the Universities of Exeter and York and published in the journal Science (14 September 2012) the research shows that, for a male over 30, the death of his mother means an almost 14-fold-increase in the likelihood of his death within the following year.
The reason for the menopause remains one of nature's great mysteries and very few species have a prolonged period of their lifespan when they no longer reproduce, as in humans. However, female killer whales stop reproducing in their 30s-40s, but can survive into their 90s. While different theories have been put forward for the evolution of menopause in humans, including the well-established 'grandmother' hypothesis, there has been no definitive answer to why females of a small number of other species, including killer whales, also stop reproducing part-way through their lives.
The research team, from the Universities of Exeter and York (UK), the Center for Whale Research (USA) and Pacific Biological Station (Canada) analysed records spanning 36 years, of the members of two populations of killer whales (Orcinus orca) in the North Pacific ocean, off the coast of the USA and Canada.
They found that the presence of a female who was no longer reproducing significantly increased her older offspring's survival. In the case of males over the age of 30, a mother's death meant a 14-fold increase in the likelihood of their death within a year. Females also stay within their mother's group but for daughters of the same age, the difference is just under three-fold. For females under the age of 30, the death of their mothers had no effect on their survival rates.
Killer whales live in unusual social groups, with sons and daughters staying with their mothers in a single group throughout their lives. With this close association, older mothers have the opportunity to increase the transmission of their genes by helping their adult offspring survive and reproduce. When sons mate, their offspring are cared for by females in another group, whereas when daughters reproduce the offspring stay in the group, which increases local competition for resources within the group.
Theory predicts that in order to have the best chance of spreading their genes, without carrying an additional burden, mothers should focus their efforts on their sons. This research backs up this theory and demonstrates the extent to which older sons are dependent on their mothers for survival.
Lead author on the paper University of Exeter PhD student Emma Foster said: "Killer whales are extraordinary animals and their social groups are really unusual in that mothers and their sons are lifelong companions. Our research suggests that they have developed the longest menopause of any non-human species so that they can offer this level of commitment to their older offspring."
Dr Dan Franks, from the Department of Biology at the University of York, said: "Our analysis shows that male killer whales are pretty much mommy's boys and struggle to survive without their mother's help. The need for mothers to care for their sons into adulthood explains why killer whales have evolved the longest post-reproductive lifespan of any non-human animal."
Dr Darren Croft of the University of Exeter added: "Both humans and killer whales are unusual in having a long menopause. Although they share this trait, the way older females benefit from ceasing reproduction differs, reflecting the different structure of human and killer whale societies. While it is believed that the menopause evolved in humans partly to allow women to focus on providing support for their grandchildren, it seems that female killer whales act as lifelong carers for their own offspring, particularly their adult sons. It is just incredible that these sons stick by their mothers' sides their entire lives."
###
This research was supported by the Biotechnology and Biological Sciences Research Council (BBSRC), the Leverhulme Trust and Earthwatch.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 13-Sep-2012 Share ] Contact: Sarah Hoyle
s.hoyle@exeter.ac.uk
44-013-927-22062
University of Exeter
Scientists have found the answer to why female killer whales have the longest menopause of any non-human species - to care for their adult sons. Led by the Universities of Exeter and York and published in the journal Science (14 September 2012) the research shows that, for a male over 30, the death of his mother means an almost 14-fold-increase in the likelihood of his death within the following year.
The reason for the menopause remains one of nature's great mysteries and very few species have a prolonged period of their lifespan when they no longer reproduce, as in humans. However, female killer whales stop reproducing in their 30s-40s, but can survive into their 90s. While different theories have been put forward for the evolution of menopause in humans, including the well-established 'grandmother' hypothesis, there has been no definitive answer to why females of a small number of other species, including killer whales, also stop reproducing part-way through their lives.
The research team, from the Universities of Exeter and York (UK), the Center for Whale Research (USA) and Pacific Biological Station (Canada) analysed records spanning 36 years, of the members of two populations of killer whales (Orcinus orca) in the North Pacific ocean, off the coast of the USA and Canada.
They found that the presence of a female who was no longer reproducing significantly increased her older offspring's survival. In the case of males over the age of 30, a mother's death meant a 14-fold increase in the likelihood of their death within a year. Females also stay within their mother's group but for daughters of the same age, the difference is just under three-fold. For females under the age of 30, the death of their mothers had no effect on their survival rates.
Killer whales live in unusual social groups, with sons and daughters staying with their mothers in a single group throughout their lives. With this close association, older mothers have the opportunity to increase the transmission of their genes by helping their adult offspring survive and reproduce. When sons mate, their offspring are cared for by females in another group, whereas when daughters reproduce the offspring stay in the group, which increases local competition for resources within the group.
Theory predicts that in order to have the best chance of spreading their genes, without carrying an additional burden, mothers should focus their efforts on their sons. This research backs up this theory and demonstrates the extent to which older sons are dependent on their mothers for survival.
Lead author on the paper University of Exeter PhD student Emma Foster said: "Killer whales are extraordinary animals and their social groups are really unusual in that mothers and their sons are lifelong companions. Our research suggests that they have developed the longest menopause of any non-human species so that they can offer this level of commitment to their older offspring."
Dr Dan Franks, from the Department of Biology at the University of York, said: "Our analysis shows that male killer whales are pretty much mommy's boys and struggle to survive without their mother's help. The need for mothers to care for their sons into adulthood explains why killer whales have evolved the longest post-reproductive lifespan of any non-human animal."
Dr Darren Croft of the University of Exeter added: "Both humans and killer whales are unusual in having a long menopause. Although they share this trait, the way older females benefit from ceasing reproduction differs, reflecting the different structure of human and killer whale societies. While it is believed that the menopause evolved in humans partly to allow women to focus on providing support for their grandchildren, it seems that female killer whales act as lifelong carers for their own offspring, particularly their adult sons. It is just incredible that these sons stick by their mothers' sides their entire lives."
###
This research was supported by the Biotechnology and Biological Sciences Research Council (BBSRC), the Leverhulme Trust and Earthwatch.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-09/uoe-lma091112.php
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{cptn}","template_name":"ss_thmb_play_ttle","i18n":{"end_of_gallery_header":"End of Gallery","end_of_gallery_next":"View Again"},"metadata":{"pagination":"{firstVisible} - {lastVisible} of {numItems}","ult":{"spaceid":"2145868275","sec":""}}},{"id": "hcm-carousel-18698039", "dataManager": C.dmgr, "mediator": C.mdtr, "group_name":"hcm-carousel-18698039", "track_item_selected":1,"tracking":{ "spaceid" : "2145868275", "events" : { "click" : { "any" : { "yui-carousel-prev" : { "node" : "a", "data" : {"sec":"HCMOL on article right rail","slk":"prev","itc":"1" }, "bubbles" : true, "test": function(params){ var carousel = params.obj.getCarousel(); var pages = carousel._pages; // if same page, don't beacon if(("_ult_current_page" in carousel) && carousel._ult_current_page==pages.cur) return false; // keep track of current position within this closure carousel._ult_current_page = pages.cur; return true; } }, "yui-carousel-next" : { "node" : "a", "data" : {"sec":"HCMOL on article right rail","slk":"next","itc":"1" }, "bubbles" : true, "test": function(params){ var carousel = params.obj.getCarousel(); var pages = carousel._pages; // no more pages, don't beacon again // if same page, don't beacon if(("_ult_current_page" in carousel) && carousel._ult_current_page==pages.cur) return false; // keep track of current position within this closure carousel._ult_current_page = pages.cur; return true; } } } } } } })); }); Y.later(10, this, function() {Y.namespace("Media").ywaSettings = '"projectId": "10001256862979", "documentName": "", "documentGroup": "", "ywaColo" : "vscale3", "spaceId" : "2145868275" ,"customFields" : { "12" : "classic", "13" : "story" }'; Y.Media.YWA.init(Y.namespace("Media").ywaSettings); }); Y.later(10, this, function() {(function() { try{ if (Math.floor(Math.random()*10) == 1) { var loc = window.location, decoded = decodeURI(loc.pathname), encoded = encodeURI(decoded), uri = loc.protocol + "//" + loc.host + encoded + ((loc.search.length > 0) ? loc.search + '&' : '?') + "_cacheable=1", xmlhttp; if (window.XMLHttpRequest) xmlhttp=new XMLHttpRequest(); else xmlhttp=new ActiveXObject("Microsoft.XMLHTTP"); xmlhttp.open("GET",uri,true); xmlhttp.send(); } }catch(e){} })(); }); Y.later(10, this, function() {if(document.onclick===YAHOO.Media.PreventDefaultHandler.newClick){document.onclick=YAHOO.Media.PreventDefaultHandler.oldClick;} }); }); });
Source: http://news.yahoo.com/nfl-player-charged-domestic-battery-florida-224941307--nfl.html
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