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Tuesday, April 2, 2013

March Podcast Roundup | YNAB - You Need A Budget

We hope that you enjoyed the great podcasts during March!

072 ? Sowing Seeds of Money Happiness ? What causes discontent with money? What influences how you spend your money, what you value, and whether you?re truly happy?

073 ? Your Life on a Treadmill ? Anyone can keep pace when the treadmill is level, you?re not carrying any extra weight, and the speed is slow. But what happens when Big Events change that? What drove you to the point where you thought, ?We need a budget!??

?074 ? Your Kids Need a Budget ? I take a few minutes to explain how we use YNAB with the kids.? We have five kids, so there?s proof that it scales.

075- How I Tripled My Money in the Stock Market ? It involved a company that made karaoke machines. I got lucky.

If you want to subscribe to the podcast, you can do so?over at iTunes, or through?this RSS link.

Source: http://www.youneedabudget.com/blog/2013/march-podcast-roundup-2/

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Break Out a Hammer: You?ll Never Believe the Data ?Wiped? Smartphones Store

Few things are more precious, intimate and personal than the data on your smartphone, which explains why you wipe it before sending it off to a recycler or selling it on eBay, right? Problem is, even if you do everything ...

Source: http://feedproxy.google.com/~r/GearFactor/~3/FlAXDfNGTEk/

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Monday, April 1, 2013

Research deciphers HIV attack plan: How AIDS virus grooms its assault team

Apr. 1, 2013 ? A new study by Los Alamos National Laboratory and University of Pennsylvania scientists defines previously unknown properties of transmitted HIV-1, the virus that causes AIDS. The viruses that successfully pass from a chronically infected person to a new individual are both remarkably resistant to a powerful initial human immune-response mechanism, and they are blanketed in a greater amount of envelope protein that helps them access and enter host cells.

These findings will help inform vaccine design and interpretation of vaccine trials, and provide new insights into the basic biology of viral/host dynamics of infection.

During the course of each AIDS infection, the HIV-1 virus evolves within the infected person to escape the host's natural immune response and adapt to the local environment within the infected individual. Because HIV evolves so rapidly and so extensively, each person acquires and harbors a complex, very diverse set of viruses that develops over the years of their infection. Yet when HIV is transmitted to a new person from their partner, typically only a single virus from the diverse set in the partner is transmitted to establish the new infection.

The key discoveries here are the specific features that distinguish those specific viruses which successfully move to the new host, compared with the myriad forms in the viral population present in a chronically infected individual.

"The viruses that make it through transmission barriers to infect a new person are particularly infectious and resilient," said Los Alamos National Laboratory scientist Bette Korber. "Through this study we now better understand the biology that defines that resilience."

The team set out to determine whether the viruses that were successfully transmitted to a new patient might share distinct biological properties relative to those typically isolated from people with long-term, chronic infection. To do this, the group at U Penn cloned a set of intact viruses from acute infection, and a set of viruses from chronically infected people, and characterized them by measuring quantities that might be related to the virus's ability to successfully establish a new infection. They discovered several clear correlations. For example, transmitted viruses were both more infectious and contained more protective "envelope" per virus; envelope is the protein the virus uses to enter host cells.

The team identified an additional interesting property that could be a general characteristic of new viral infections: the transmitted HIV was capable of replicating and growing well in the presence of alpha interferon. Alpha interferon production is part of our innate human immune response to a new infection. As soon as a new viral infection is initiated in our bodies, local immune cells at the site of infection start secreting molecules called cytokines that have general antiviral activity and can inhibit the production of the newly infected virus. Alpha interferon is one of these potent cytokines.

In the early days of an HIV infection, this innate immune response increases to an intense level, called a "cytokine storm," which gradually recedes during infection. For a newly transmitted HIV to successfully establish infection, it must grow and expand in the new host while facing this cytokine storm. Although typical chronic viruses are sensitive to and inhibited by alpha interferon, transmitted HIV-1 viruses grew well in the presence of interferon.

Los Alamos scientists Elena Giorgi, James Theiler and Bette Korber were part of the analysis team working closely with investigators at the University of Pennsylvania, Nick Parrish and Beatrice Hahn. The paper, "Phenotypic properties of transmitted founder HIV-1" is in this week's issue of Proceedings of the National Academy of Sciences.

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Story Source:

The above story is reprinted from materials provided by DOE/Los Alamos National Laboratory.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

N. F. Parrish, F. Gao, H. Li, E. E. Giorgi, H. J. Barbian, E. H. Parrish, L. Zajic, S. S. Iyer, J. M. Decker, A. Kumar, B. Hora, A. Berg, F. Cai, J. Hopper, T. N. Denny, H. Ding, C. Ochsenbauer, J. C. Kappes, R. P. Galimidi, A. P. West, P. J. Bjorkman, C. B. Wilen, R. W. Doms, M. O'Brien, N. Bhardwaj, P. Borrow, B. F. Haynes, M. Muldoon, J. P. Theiler, B. Korber, G. M. Shaw, B. H. Hahn. Phenotypic properties of transmitted founder HIV-1. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1304288110

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/N3tNW197Jd4/130401132056.htm

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Drug maker Novartis loses India patent battle

FILE - In this Thursday, Feb. 9, 2012 file photo, a pharmacist works in a lab where medicines are being produced at a Cipla manufacturing unit on the outskirts of Mumbai, India. A lawyer for healthcare activists says India's Supreme Court has rejected drug maker Novartis AG' right to patent a new version of a lifesaving cancer drug. The landmark ruling today is a victory for India's (Canadian) $26 billion generic drug industry that provides cheap medicines to millions around the world. Novartis has fought a legal battle in India since 2006 for a fresh patent for its cancer drug Glivec. Cipla makes a generic version of Glivec. (AP Photo/Rafiq Maqbool, File)

A billboard for wholesale rate of cancer medicines is seen outside a chemist store, in New Delhi, India, Monday, April 1, 2013. India's Supreme Court on Monday rejected drug maker Novartis AG's attempt to patent a new version of a cancer drug Glivec in a landmark decision that healthcare activists say ensures poor patients around the world will get continued access to cheap versions of lifesaving medicines. (AP Photo/Manish Swarup)

FILE - In this Monday, Jan. 29, 2007 file photo, Indian police officers block demonstrators protesting against drug manufacturer Novartis' case against Indian government on drug patents in New Delhi, India. A lawyer for healthcare activists says India's Supreme Court has rejected drug maker Novartis AG' right to patent a new version of a lifesaving cancer drug. The landmark ruling Monday, April 1, 2013 is a victory for India's $26 billion generic drug industry that provides cheap medicines to millions around the world. Novartis has fought a legal battle in India since 2006 for a fresh patent for its cancer drug Glivec. (AP Photo/Saurabh Das, File)

FILE - In this Thursday, Feb. 9, 2012 file photo, a man walks past the Cipla manufacturing unit on the outskirts of Mumbai, India. India's Supreme Court on Monday rejected drug maker Novartis AG's attempt to patent a new version of a cancer drug in a landmark decision that healthcare activists say ensures poor patients around the world will get continued access to cheap versions of lifesaving medicines. Novartis had argued that it needed a new patent to protect its investment in the cancer drug Glivec, while activists said the company was trying to use loopholes to make more money out of a drug whose patent had expired. Cipla makes a generic version of Glivec. (AP Photo/Rafiq Maqbool, File)

NEW DELHI (AP) ? India's Supreme Court on Monday rejected drug maker Novartis AG's attempt to patent an updated version of a cancer drug in a landmark decision that health activists say ensures poor patients around the world will get continued access to cheap versions of lifesaving medicines.

Novartis had argued that it needed a patent to protect its investment in the cancer drug Glivec, while activists said the drug did not merit intellectual property protection in India because it was not a new medicine. In response to the ruling, Novartis said it would not invest in drug research in India.

The court's decision has global significance since India's $26 billion generic drug industry, which supplies much of the cheap medicine used in the developing world, could be stunted if Indian law allowed global drug companies to extend the lifespan of patents by making minor changes to medicines.

Once a drug's patent expires, generic manufacturers can legally produce it. They are able to make drugs at a fraction of the original manufacturer's cost because they don't carry out the expensive research and development.

Pratibha Singh, a lawyer for the Indian generic drug manufacturer Cipla, which makes a version of Glivec for less than a tenth of the original drug's selling price, said the court ruled that a patent could only be given to a new drug, and not to those which are only slightly different from the original.

"Patents will be given only for genuine inventions, and repetitive patents will not be given for minor tweaks to an existing drug," Singh told reporters outside the court.

Novartis called the ruling a "setback for patients," and said patent protection is crucial to fostering investment in research to develop new and better drugs.

Ranjit Shahani, the vice chairman and managing director of Novartis India, said the ruling "will hinder medical progress for diseases without effective treatment options."

He said the court's decision made India an even less attractive country for major investments by international pharmaceutical companies.

"Novartis will not invest in drug research in India. Not only Novartis, I don't think any global company is planning to research in India," he said.

The Swiss pharmaceutical giant has fought a legal battle in India since 2006 to patent a new version of Glivec, which is mainly used to treat leukemia and is known as Gleevec outside India and Europe. The earlier version of Glivec did not have an Indian patent because its development far predated the country's 2005 patent law. Novartis said Glivec is patented in nearly 40 other countries.

India's patent office rejected the company's patent application, arguing the drug was not a new medicine but an amended version of its earlier product. The patent authority cited a provision in the 2005 patent law aimed at preventing companies from getting fresh patents for making only minor changes to existing medicines ? a practice known as "evergreening."

Novartis appealed, arguing the drug was a more easily absorbed version of Glivec and that it qualified for a patent.

Anand Grover, a lawyer for the Cancer Patients Aid Association, which led the legal fight against Novartis, said the ruling Monday prevented the watering down of India's patent laws.

"This is a very good day for cancer patients. It's the news we have been waiting for for seven long years," he said.

Aid groups, including Medicins Sans Frontieres, have opposed Novartis' case, fearing that a victory for the Swiss drugmaker would limit access to important medicines for millions of poor people around the world.

Glivec, used in treating chronic myeloid leukemia and some other cancers, costs about $2,600 a month. Its generic version was available in India for around $175 per month.

"The difference in price was huge. The generic version makes it affordable to so many more poor people, not just in India, but across the world," said Y.K. Sapru, of the Mumbai-based cancer patients association.

"For cancer sufferers, this ruling will mean the difference between life and death. Because the price at which it was available, and considering it's the only lifesaving drug for chronic myeloid cancer patients, this decision will make a huge difference," Sapru said.

Leena Menghaney of Medicins Sans Frontieres said India would continue to grant patents on new medicines.

"This doesn't mean that no patents will be granted. Patents will continue to be granted by India, but definitely the abusive practice of getting many patents on one drug will be stopped," Menghaney said.

The judgment would ensure that the prices of lifesaving drugs would come down as many more companies would produce generic versions.

"We've seen this happening with HIV medicines, where the cost of HIV treatment has come down from $10,000 to $150 per year. Cancer treatment costs have come down by 97 percent in the case of many cancer drugs," she said.

"This decision is incredibly important. The Supreme Court decision will save a lot of lives in the coming decades," Menghaney said.

___

AP writer Kay Johnson contributed to this story from Mumbai, India.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-04-01-India-Patent%20Battle/id-71f81996771a408dbdaa97724d1f7822

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sales teleselling: Explore Transforming From Outside Sales to ...

AppId is over the quota
AppId is over the quota

Transforming your team from outside sales to telesales:

The ability to adapt to the conditions we face may be the only thing that keeps us alive. During these troubled and changing times you must have the ability to learn at a very fast pace. The age of the computer and internet has been ongoing now for over thirty years and it's not looking back.

Going from one form of sales to another requires very different tools and skills. In outside sales your ability to use your physical traits such as a warm smile, firm hand shake or silly expression are all powerful tools. The personal traits that we reference to as being full of "piss and vinegar" don't mean as much today as in the good old days. Many experts teach you to look into a customer's eyes and hold their arm as a symbol of honesty and integrity. In telesales those tools are gone; the ability to communicate is strictly by voice reflections and the written words in text and e-mails.

No longer do you have a choice, becoming a telesales rep is a necessary tool that will help your future employment in sales. While fuel prices and the cost of doing business continue to skyrocket, the cost to sell by telephone has been dramatically reduced. The internet and mobile phone have completely revolutionized the way sales are conducted today! Outside sales has been replaced by web-sites, lead generation software, Facebook and Twitter. The ability to post videos of sales presentations, information, and products on YouTube is simple and extremely fast, this is a must for the new sales techniques.

Telesales will allow you to extend your career, embracing the change from outside sales is a must. No longer will you physically go out and visit your customer, your customer is but a phone call away. You can send him a quote,proposal,or new bit of product information with a click of a mouse. No longer will you have to sit in a lobby and wait endlessly for your customer to "see you now"! The days of dragging and carrying catalogs and brochures up flights of stairs and elevators are over, a virtual catalog is online or sent via PDF file directly to them. Promotional flyers, newsletters and sales letters, are now included in power point presentations and videos and streamlined directly to customers anywhere in the world!

The results have been proven; whether your business is selling appliance, electronics, plants or even office furniture, The new way is better of sales is better, quicker and more efficient. Sales are now conducted world-wide and the cost of the sales have been reduced to almost nothing. A great web-site and a tremendous inside telesales force will bring you an ability to sell your products to the anyone in the country and beyond. As someone once said "GO FOR IT".

Source: http://bestsalesteleselling.blogspot.com/2013/03/explore-transforming-from-outside-sales.html

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Source: http://chancewilkins.typepad.com/blog/2013/03/sales-teleselling-explore-transforming-from-outside-sales-to.html

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AP: Gas trade group seeks fracking probe

ALBANY, N.Y. (AP) ? A formal complaint filed with New York's lobbying board asks it to investigate whether Artists Against Fracking, a group that includes Yoko Ono and other A-List celebrities, is violating the state's lobbying law, according to the document obtained by The Associated Press.

The Independent Oil & Gas Association, an industry group that supports gas drilling, filed the complaint Tuesday with the state's Joint Commission on Public Ethics.

The complaint is based on an AP story that found that Artists Against Fracking and its members, including Ono, her son Sean Lennon, actors Mark Ruffalo and Robert De Niro and others, aren't registered as lobbyists and therefore didn't disclose their spending in opposition to hydraulic fracturing, or fracking, to remove gas from underground deposits.

"The public has been unable to learn how much money is being spent on this effort, what it is being spent on, and who is funding the effort," said Brad Gill, executive director of the Independent Oil & Gas Association of New York. "I understand the power of celebrity that this organization has brought to the public discussion over natural gas development, but I do not understand why this organization is not being required to follow the state's lobbying law."

The group confirmed it filed the complaint but didn't comment further.

Artists Against Fracking, formed by Ono and Lennon, says its activities are protected as free speech. The group was created last year amid the Cuomo administration's review to determine whether to allow hydraulic fracturing to remove gas from vast underground shale formations in southern and central New York.

Gov. Andrew Cuomo continues his review as public opinion has shifted from initial support based on the promise of jobs and tax revenue from drilling in economically depressed upstate New York to mixed feelings because of concerns over potential environmental and health effects.

Seven months after Artists Against Fracking was formed, the Quinnipiac University Polling Institute on March 20 found that New York voters were for the first time opposed to fracking, 46 percent to 39 percent.

"There's no doubt the celebrities had an effect," Quinnipiac pollster Maurice Carroll said. "As far as I can tell, they made all the difference."

A spokesman for Artists Against Fracking said the group and its individual members don't have to register as lobbyists.

"As private citizens, Yoko and Sean are not required to register as lobbyists when they use their own money to express an opinion and there's also no lobbying requirement when you are engaged in a public comment period by a state agency," spokesman David Fenton said.

"If the situation changes then, of course, Artists Against Fracking will consider registering," Fenton said. "Up to now, there has been no violation because they are entitled to do this as private citizens with their own money."

On its website, the group implores readers: "Tell Governor Cuomo: Don't Frack New York." Celebrities supporting the group have led rallies and performed in the song "Don't Frack My Mother," also carried on the Internet.

Ethics commission spokesman John Milgrim didn't immediately respond to a request for comment on Friday. By law, the commission doesn't confirm or deny pending investigations.

New York's former lobbying regulator, attorney David Grandeau, said he believed the group and the supporting artists, including musicians Paul McCartney and Lady Gaga and actress Anne Hathaway, should be registered and required to disclose details on their efforts to spur public opposition to gas drilling.

"When you are advocating for the passage or defeat of legislation or proposed legislation and spend more than $5,000, you are required to register," Grandeau said Friday. "Just because you are a celebrity doesn't mean that lobbing laws don't apply to you. Your celebrity status does not protect you in Albany."

Hip-hop mogul Russell Simmons and developer Donald Trump are among the high-profile figures who clashed with the commission when Grandeau was regulator. The biggest penalty for failure to follow the lobbying law resulted in a $250,000 fine against Trump and others over casinos in 2000.

Source: http://news.yahoo.com/apnewsbreak-gas-trade-group-seeks-fracking-probe-172054771.html

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UIDAI shocker: 1,000 Aadhar forms found in Mumbai society office

http://www.mid-day.com/news/2013/mar/300313-uidai-shocker-1000-aadhar-forms-found-in-mumbai-society-office.htm

http://images.mid-day.com/2013/mar/aadhar-forms.jpg

UIDAI shocker: 1,000 Aadhar forms found in Mumbai society office

In July 2011, an Aadhar camp was held in a Jogeshwari colony; till date all the documents residents submitted and their original Aadhaar forms are lying in a cupboard, despite repeated reminders to authorities to take them away

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In order to get their ?unique? identities in the form of Aadhaar cards, citizens first have to submit documents in proof of their ?regular? identities ? PAN card details, passport copies, bank details, and other significant personal documents that testify for their age, date of birth and address.

Gathering dust: Over 1,000 residents had participated in the Aadhaar camp and provided their PAN card details with the hard copy of the form. Almost two years from submission, the documents have still not been picked up by the concerned authorities. Pics/Kiran Bhalerao

But is your identity, or at least the documents that prove it, safe with agencies deployed by the UIDAI to provide you your ?unique? identity? A recent discovery by MiD DAY gives evidence to the contrary. In yet another glaring instance of carelessness, sensitive documents of over 1,000 Aadhaar applicants ? including PAN cards, hard copies of forms, and bank details ? have been lying in a state of neglect in the cupboard of a housing society in Jogeshwari (West), in the room where an Aadhaar camp was organised for residents almost two years ago.

Aadhaar camp
In July 2011, Malcolm Baug, a colony in Jogeshwari (West), organised an Aadhaar camp for residents and neighbouring societies in the area. Their aim was to make the enrollment process easy for the people. Over 1,000 people from the area participated in the camp, making it a huge success.

Almost two years have passed since, and many of the residents are now proud owners of Aadhaar cards. However, copies of the compulsory documents they had submitted as proof of identity, as well as hard copies of the forms, were left behind by the agency that filed the data. Farokh Shaher, secretary of the Malcolm Baug Zoroastrian Association said, ?On July 17, 2011, we organised an Aadhaar camp for our residents. We had spoken to the authorities and set up a centre at the community centre. The camp was a big success but it?s been almost two years now, and the documents which they had asked for from applicants continue to lie in our office.?

He added, ?We have spoken at least 10 times to the enrollment agency in charge of data collection for Aadhaar cards in the colony ? asking them to collect the documents. Each time, we were told that they would send an authorised representative to collect the papers in two days. But no one turned up. It is shocking that such sensitive information is lying around in sorry neglect. Reposing their trust in the authorities, the residents of the colony provided copies of address proof and date of birth. But they had no idea that their information would be left like this.?

Threat of data theft
An office bearer expressed relief at the fact that the copies and the forms are lying in the cupboard and not elsewhere, in which case the data could easily be misused by others.

Shaher added that even though he has sent a slew of e-mails to the Aadhaar helpline in January, no one has contacted him yet. The documents and forms of over 1,000 people continue to lie in the office cupboard. ?We don?t know if we should return the residents their information or continue to wait for a reply from the Aadhaar officials.?

?True shame?
MiD DAY contacted a few residents of the society, who expressed shock and outrage at the news. ?How can officials not take care of the documents? We provide them with copies of our PAN cards and even our bank details and, it?s not even protected. It?s a true shame,? said a resident.

Another resident scoffed at the Aadhaar enrollment programme, pointing out that it made no sense to ask for hard copies of documents when the process was being conducted online. ?The whole thing is a joke,? he added.

The Other Side
An official from the UID regional office said, ?Data collection is the responsibility of the enrollment agency. We provide them with a definite timeframe in which to provide us with the data packages. During phase I, in which the residents enrolled for the cards, there were a few errors owing to which the documents were left behind. However, in phase II no such errors are occurring.?

Santosh Bhogle, state nodal UID officer and undersecretary, IT department of Maharashtra, expressed shock at the situation. ?It is very wrong that these hard copies and documents are lying unattended. People trustingly provide their details, what has occurred is unfortunate. It was the responsibility of the agency responsible for data collection to submit the documents for processing to the government,? he said.?

Source: http://www.mid-day.com/news/2013/mar/300313-uidai-shocker-1000-aadhar-forms-found-in-mumbai-society-office.htm

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